Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor)
نویسندگان
چکیده
منابع مشابه
Prostaglandins Cell Culture Pcr CYCLOOXYGENASE-TWO REGULATES PROLIFERATION IN AGGRESSIVE FIBROMATOSIS (DESMOID TUMOR)
Introduction: Aggressive fibromatosis (desmoid tumor) is a locally invasive soft tissue lesion, composed of a monoclonal proliferation of benignappearing spindle (fibroblast like) cells. A subset of lesions contain a somatic mutation in the adenomatous polyposis coli (APC) gene (1). Familial Adenomatosis Polyposis (FAP) is an inherited pre-neoplastic condition that predisposes to colonic neopla...
متن کاملAggressive Desmoid Tumor Mimicking Breast Cancer
sive disease (1). An accurate diagnosis is difficult because of the similar clinical and imaging findings to a breast malignancy. Desmoid tumors are found mainly in young women and in patients with previous surgical trauma or reconstruction. We report the case of a 72year-old female presenting with an aggressive desmoid tumor that mimicked breast carcinoma but was not associated with previous t...
متن کاملCyclooxygenase-2 and platelet-derived growth factor receptors as potential targets in treating aggressive fibromatosis.
PURPOSE To explore the molecular bases of potential new pharmacologic targets in aggressive fibromatosis (desmoid tumor). EXPERIMENTAL DESIGN Tumor specimens from 14 patients surgically treated for aggressive fibromatosis (6 familial adenomatous polyposis and 8 sporadic cases), analyzed for adenomatous polyposis coli (APC) and CTNNB1 (beta-catenin) mutations, were further investigated for bet...
متن کاملDesmoid tumor (fibromatosis) of the head and neck
نم أشنت .ةردان ةديمح ماروأ يه )ةيفيللا( ةيطابرلا مارولأا عباط تاذ يهو .مسلجا ءاحنأ عيمج يف ةيلضعلا لكايهلا لدعم عافترا ىلإ ىدأ امم ، ةرواجلما هيللمحا ةجسنلأل يحاشترا ةردنل ًارظن و .يحارلجا لاصئتسلاا دعب مرولا عوجر ةبسنو نع غلابلإاب انمق اننإف ، ةبقرلاو سأرلا ةقطنم يف مارولأا هذه يف اهجلاعو قنعلا ىلعأ يف يطابرلا مرولاب اهصيخشت تم ةلاح جلاعل هرفوتلما تارايلخاو قرطلا لوح يعولا ةدايزل ،انافشتسم .ةبق...
متن کاملActivity of Sorafenib against desmoid tumor/deep fibromatosis.
BACKGROUND Desmoid tumors (deep fibromatoses) are clonal connective tissue malignancies that do not metastasize, but have a significant risk of local recurrence, and are associated with morbidity and occasionally mortality. Responses of desmoid patients to sorafenib on an expanded access program led us to review our experience. METHODS After Institutional Review Board (IRB) approval, we revie...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2001
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1204107